Call for Abstract
12th International Conference and Exhibition on Metabolomics
(10 Plenary Forums - 1 Event), will be organized around the theme “Metabolomics, a promising approach to Cancer, Cardiovascular disease and immunology”
Metabolomics Meeting 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Metabolomics Meeting 2018
Submit your abstract to any of the mentioned tracks.
Register now for the conference by choosing an appropriate package suitable to you.
Metabolic profiling is the measurement in biological systems of the complement of low-molecular-weight metabolites and their intermediates that reflects the dynamic response to genetic modification and physiological, pathophysiological, and/or developmental stimuli. The measurement and interpretation of the endogenous metabolite profile from a biological sample (typically urine, serum, or biological tissue extract) have provided many opportunities to investigate the changes induced by external stimuli (e.g., drug treatment) or enhance our knowledge of inherent biological variation within subpopulations.
Metabolomics is a data intensive discipline whose workflow is characterized by extensive use of databases. Database applications range from compound identification (e.g. exact mass, GC-EI spectrum or MS/MS spectrum comparison) to data integration and visualization (assignment of compounds to reactions, pathways, cell compartments, etc.).Metabolomics is a newborn cousin to genomics and proteomics. Specifically, metabolomics involves the rapid, high throughput characterization of the small molecule metabolites found in an organism. The metabolome is closely tied to the genotype of an organism, its physiology and its environment (what the organism eats or breathes), metabolomics offers a unique opportunity to look at genotype-phenotype as well as genotype-envirotype relationships. Metabolomics is increasingly being used in a variety of health applications including pharmacology, pre-clinical drug trials, toxicology, transplant monitoring, newborn screening and clinical chemistry. However, a key limitation to metabolomics is the fact that the human metabolome is not at all well characterized.
- Track 2-1NMR spectral databases
- Track 2-2MS or MS/MS spectral databases
- Track 2-3Compound databases
- Track 2-4Pathway databases
- Track 2-5Comprehensive metabolomic databases
- Track 2-6Yeast metabolome database
- Track 2-7The human serum metabolome database
- Track 2-8The urine metabolome database
Metabolomics is a relatively young branch of “omics” science concerned with the systematic study of the chemical products or metabolites that cells and organisms generate. Because metabolites are the downstream products of numerous genome-wide or proteome-wide interactions, the metabolome (the sum of all metabolites in an organism) can be a very sensitive measure of an organism’s phenotype. This fact has made metabolomics particularly useful in the study of environment-gene interactions, the identification of disease biomarkers and the discovery of drugs. Unlike its older “omics” cousins, where complete or near-complete coverage of the genome or proteome is fairly routine, metabolomics still struggles to cover even a tiny fraction of the metabolome. Indeed, most human metabolomic studies published today, even those exploiting the latest and most sensitive LC-MS/MS technologies, typically succeed in identifying or characterizing fewer than 100 compounds. This corresponds to less than 1% of the known human metabolome. In an effort to help improve this situation, we (and others) have started to undertake the systematic characterization of various human biofluid metabolomes. This includes the human cerebrospinal fluid metabolome the human saliva metabolome and the human serum metabolome. We have now turned our attention to characterizing the human urine metabolome.
Metabolites can serve as a metabolic disease biomarker. An detection of such biomarkers plays a significant role in the study of biochemical reaction and signaling networks. Metabolic profiling, metabolomic and metabonomic studies mainly involve the multicomponent analysis of biological fluids, tissue and cell extracts using NMR spectroscopy and/or mass spectrometry (MS). Metabolic profiling (metabolomics/metabonomics) is the measurement in biological systems of the complement of low-molecular-weight metabolites and their intermediates that reflects the dynamic response to genetic modification and physiological, pathophysiological, and/or developmental stimuli. The current developments in metabolomics and metabolic profiling technologies have led to the discovery of several new metabolic biomarkers. The Human Metabolome Database (HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world. It contains records for more than 2180 endogenous metabolites with information gathered from thousands of books, journal articles and electronic databases. In addition to its comprehensive literature-derived data, the HMDB also contains an extensive collection of experimental metabolite concentration data compiled from hundreds of mass spectra (MS) and Nuclear Magnetic resonance (NMR) metabolomic analyses performed on urine, blood and cerebrospinal fluid samples. The HMDB is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community
The metabolome is defined as the full complement of small-molecule metabolites found in a specific cell, organ, or organism. The most interesting potential application of single-cell metabolomics may be in the area of cancer. In other fields where single-cell metabolomics is expected to have an impact are systems biology, stem cell research, aging, and the development of drug resistance; more generally, it could be used to discover cells’ chemical strategies for coping with chemical or environmental stress. Relative to other single-cell “-omics” measurements, metabolomics provides a more immediate and dynamic picture of the functionality (i.e., of the phenotype) of a cell, but is arguably also the most difficult to measure. Single-cell analysis of metabolites by mass spectrometry (MS) is challenging due to the very limited volume and inherent molecular complexity of the sample. Quantitative metabolomic analysis of individual cells provides information on the metabolic heterogeneity of cells unattainable by aggregate analysis of multiple cells. Depending on the ionization method, MS can offer quantitative analysis for a broad class of metabolites exhibiting both high sensitivity and selectivity. Laser ablation electrospray ionization (LAESI) has been successfully exploited to analyze metabolites from broad range of biological samples, including single cells and small cell populations.
Mass spectrometry (MS) has evolved as a critical component in metabolomics which seeks to answer biological questions through large-scale qualitative and quantitative analyses of the metabolome. MS based metabolomics techniques offer an excellent combination of sensitivity and selectivity, and they have become an indispensable platform in biology and metabolomics. The emerging field of metabolomics, aiming to characterize small molecule metabolites present in biological systems, promises immense potential for different areas such as medicine, environmental sciences, agronomy, etc. The rapidly growing area of "metabolomics," in which a large number of metabolites from body fluids, cells or tissue are detected quantitatively, in a single step, promises immense potential for a number of disciplines including early disease diagnosis, therapy monitoring, systems biology, drug discovery and nutritional science. Because of its ability to detect a large number of metabolites in intact biological samples reproducibly and quantitatively, nuclear magnetic resonance (NMR) spectroscopy has emerged as one of the most powerful analytical techniques in metabolomics.
Urine metabolomics has recently emerged as a prominent field for the discovery of non-invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific disease or therapeutic intervention. Urine, compared to other biofluids, is characterized by its ease of collection, richness in metabolites and its ability to reflect imbalances of all biochemical pathways within the body. Urine collection for metabolomic analysis, samples must be immediately frozen to quench any biogenic and/or non-biogenic chemical reactions. Combined with the qualitative and quantitative capabilities of MS, and due to the continuous improvements in its related technologies liquid chromatography (LC)-MS is unequivocally the most utilized and the most informative analytical tool employed in urine metabolomics. The Urine Metabolome database is a freely available electronic database containing detailed information about ~3100 small molecule metabolites found in human urine along with ~3900 concentration values. Each metabolite entry contains more than 110 data fields and many of them are hyperlinked to other databases (KEGG, PubChem, ChEBI, Chemspider, DrugBank, PDB and Uniprot). The information includes literature and experimentally derived chemical data, clinical data and molecular/biochemistry data.
Metabolomics and lipidomics, intense apparatuses in frameworks science, expect to screen little metabolites present in organic examples. Contrasts in the species or measures of metabolites can be utilized to portray phenotypes and natural reactions to annoyances (ailments, hereditary adjustments, or nutritious and pharmacological medications). The Thermo Scientific TSQ arrangement mass spectrometer instrument family, joined with high determination GC or UHPLC, gives unrivaled adaptability and affectability to chose particle response checking (SRM) tests for measuring endogenous metabolites and lipids utilizing Thermo Scientific TraceFinder and LC Quan programming. Translational Biomarker Discovery Core incorporate distinguishing, approving and creating pre-clinical biomarkers for building up the vicinity of ailment, observing reduction status, deciding the viability of particular remedial conventions, and controlling the choice of particular helpful mediations. Connecting the consequences of biomarker studies utilizing protein-protein association methodologies can help with frameworks science approaches and could prompt theory era and recognizable proof of new medication targets. Science Minister David Willetts has declared £48 million of new speculation to store research ventures went for handling wellbeing issues.
- Track 8-1Translational biomarker discovery
- Track 8-2Metabolic interactions
- Track 8-3Clinical applications of metabolomics
- Track 8-4Metabolomics and mass spectrometry
- Track 8-5Mass spec in clinical microbiology
- Track 8-6Forensic analysis
Cancer is an overwhelming sickness that changes the digestion system of a cell and the encompassing milieu. Metabolomics in pharmaceutical examination turning into an inexorably mainstream instrument in the life sciences since it is a generally quick and precise procedure that can be connected with either a specific center or in a worldwide way to uncover new learning about organic frameworks.. NFCR has conveyed more than $330 million in subsidizing to growth research prompting various leaps forward, including counteractive action methodologies, prior analytic systems, and new anticancer medications and treatments. The Division of Cancer Biology (DCB) bolsters and encourages fundamental examination in every aspect of tumor science at scholastic establishments and exploration establishments over the United States and abroad. As a major aspect of the National Cancer Institute, the Federal Government's foremost office for growth research and preparing, DCB gives financing to research that examines the fundamental science behind all events of Cancer. Current metabolomic approaches is being utilized to find symptomatic Cancer biomarkers in the clinic, to find pathways included in disease that could be utilized for new targets and to screen metabolic biomarkers amid remedial mediation. Concentrating on growth through metabolomics could uncover metabolite stage for hearty approval of biomarkers for Cancer that could be helpful for its future forecast, conclusion and treatment. There have been numerous novel ways to deal with cancer therapeutics that have utilized a scope of various explanatory stages. At the point when Cancer digestion system meets frameworks science system models might manual for growth treatment.
- Track 9-1Cancer metabolomics and diagnostic biomarkers
- Track 9-2Current metabolomic methodologies
- Track 9-3Applications of metabolomics in oncology and biomarker discovery
- Track 9-4Metabolite platform for robust validation of biomarkers
- Track 9-5Metabolomics in pharmaceutical research
- Track 9-6Cancer metabolism meets systems biology
- Track 9-7Novel approaches to cancer therapeutics
Metabolomics is the examination of endogenous and exogenous low atomic mass metabolites inside of a cell, tissue, or biofluid of a life form in light of an outer stressor. The sub-control of environmental metabolomics is the utilization of metabolomic strategies to investigate the connections of life forms with their surroundings. Drug metabolism system is the procedure by which the body separates and changes over pharmaceutical into dynamic concoction substances. Toxicology is a branch of Medical Science that arrangements with the impacts of synthetic compound utilized as a part of the conclusion, treatment, or counteractive action of ailment or other unusual condition on the body. Plant Metabolomics is to contemplate the plant framework at the sub-atomic level giving non-one-sided characterization of the total metabolite pool (metabolome) of plants under particular conditions. Using Metabolomics, a better understanding of the correlation between genes and the biochemical composition of a plant tissue in response to its environment (phenotype) can be obtained, and this information can be further used to assess gene function (genotype). Four joint U.S. also, Japanese research groups have been recompensed subsidizing totaling about $12 million (about Yen 960 million) to grow new naturally well disposed strategies to expand the creation of renewable biofuel and lessen pesticide use.
- Track 10-1Green systems biology
- Track 10-2Recent developments in environmental metabolomics
- Track 10-3NMR-based metabolomics in wine science
- Track 10-4Toxicology and drug metabolism
- Track 10-5Linking metabolomics with quality traits in crop plants
- Track 10-6Applications of metabolomics in plant metabolomics
- Track 10-7Toxicometabolomics
Metabolomics is connected to research a few human illnesses, to enhance their determination and aversion, and to outline better helpful systems. Metabolomic profiling has been utilized to distinguish novel biomarkers and mechanisms of cardiovascular disease risk. Nourishment and Metabolism Center and Center for Human Genetics at Duke University where the examination is going ahead with National Institutes of Health awards . Metabolomics can give certain preferences in respect to other "omics" advancements (genomics, transcriptomics, proteomics) in diabetes research. CEDAM (Center for Endocrinology, Diabetes and Metabolism) exploration is focused on a seat to-bedside approach, taking examination through from fundamental science disclosure to clinical application. This is encouraged by ebb and flow MRC Experimental Medicine and Biomarker Grants and improved by the nearby vicinity of lab offices, Wellcome Trust Clinical Research Facility and the Queen Elizabeth Hospital (University Hospital NHS Foundation Trust). Metabolomic approach gives novel experiences into the mechanistic studies of antitumor medications from a point particular from traditional medicine investigations. Different new advancements have be utilized for technique improvement of metabolomics. Specialized advances have prodded the use of metabolomics in an assortment of various examination zones spreading over essential, biomedical, and clinical sciences.
- Track 11-1Metabolomics in cardiovascular diseases
- Track 11-2Metabolism and diabetes
- Track 11-3Metabolomics and mechanistic study
- Track 11-4Methodology development of metabolomics
- Track 11-5Metabolomics and traditional medicine study
- Track 11-6Metabolic and endocrine science
Metabolism is an essential pharmacokinetic process, which renders lipid soluble and non-polar compounds to water soluble and polar compounds so that they are excreted by various processes. This is because only water-soluble substances undergo excretion, whereas lipid soluble substances are passively reabsorbed from renal or extra renal excretory sites into the blood by virtue of their lipophilicity. Metabolism is a necessary biological process that limits the life of a substance in the body. Xenobiotics : These are all chemical substances that are not nutrient for body (foreign to body) and which enter the body through ingestion, inhalation or dermal exposure. They include : drugs, industrial chemicals, pesticides, pollutants, plant and animal toxins, etc.
- Track 12-1Biotransformation of Drugs
- Track 12-2Sites of Biotransformation
- Track 12-3Subcellular Location of Metabolizing Enzymes
- Track 12-4Drug Metabolizing Enzymes
- Track 12-5Factors Affecting Metabolizing Enzymes