Metabolism of Drugs

Metabolism is an essential pharmacokinetic process, which renders lipid soluble and non-polar compounds to water soluble and polar compounds so that they are excreted by various processes.   This is because only water-soluble substances undergo excretion, whereas lipid soluble substances are passively reabsorbed from renal or extra renal excretory sites into the blood by virtue of their lipophilicity. Metabolism is a necessary biological process that limits the life of a substance in the body. Xenobiotics : These are all chemical substances that are not nutrient for body (foreign to body) and which enter the body through ingestion, inhalation or dermal exposure. They include :  drugs, industrial chemicals, pesticides, pollutants, plant and animal toxins, etc.

  • Biotransformation of Drugs
  • Sites of Biotransformation
  • Subcellular Location of Metabolizing Enzymes
  • Drug Metabolizing Enzymes
  • Factors Affecting Metabolizing Enzymes

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