Wayne State University
My current research focuses on combining metabolomics, a new and exciting post genomic technology with the power of bioinformatics tools for studying perturbations in metabolism caused due to changes in diet and/or the disease state. In one of our projects, we are investigating the change in the metabolomic patterns produced due to introduction of neutraceuticals in non-small cell lung carcinoma model. The NMR spectral data is subjected to Principal Component Analysis (PCA) to evaluate Biomarkers for early diagnosis of lung cancer. In another project, we are utilizing the metabolomics approach to observe alterations in metabolomics patterns in NMR spectra of biofluids (urine/plasma) from a spontaneous diabetes model. The change in metabolomic pattern or the biomarker profile will enable targeting of specific metabolic pathways affected by the disease condition, leading to mechanistic insight.