Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer


4th International Conference and Exhibition on Metabolomics & Systems Biology

Philadelphia, USA

Marvin W. Makinen

Marvin W. Makinen

The University of Chicago, USA

Title: Preferential sequestration of a vanadyl chelate by cancer tissue facilitates 2-(fluorine-18)-2-deoxyglucose (FDG)


Biography: Marvin W. Makinen


PET imaging with FDG as the tracer molecule for cancer detection is biochemically based and is associated with high specificity. However, FDG PET imaging relies on tumor size and the local metabolic characteristics of the type of cancer. Some breast cancer types characterized by low glucose uptake give rise to false negatives. Bis (acetylacetonato) oxidovana-dium (IV) [VO (acac)2] exhibits high stability in solution and displays a high capacity to enhance cellular glucose uptake. We observed that enhanced FDG uptake by MDA-MB-231 cultured human breast carcinoma cells was facilitated by VO(acac)2 over the 1–8 μM range in the presence of a background 5 mM glucose concentration, equivalent to the fasting level of blood glucose in a normal adult. Generating MDA-MB-231 xenograft tumors in SCID mice, we observed maximum FDG uptake approximately 4 hours post-VO(acac)2 injection. This observation closely correlates with the time of 3.5-4 hours for maximum preferential sequestration of the chelate by tumor tissue. Longer intervals between intraperitoneal injection of VO(acac)2 and the onset of FDG PET imaging showed decreased FDG uptake. We have observed up to 6-fold enhanced FDG uptake compared to controls with a two-fold higher dose of VO(acac)2. These preliminary results indicate that use of VO(acac)2 as a pharmacologic agent to enhance FDG uptake by malignant tissue has the potential to improve detection of both small tumors and tumors of low metabolic activity by FDG PET imaging.

Speaker Presentations

Speaker PDFs

Speaker PPTs Click Here