Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer


5th International Conference and Exhibition on Metabolomics

Osaka, Japan

Kazuhiro Ogata

Kazuhiro Ogata

Yokohama City University Graduate School of Medicine, Japan

Title: Molecular Mechanism for modulationof a multiple transcriptionfactorcomplexformed on enhancer site upon phosphorylation


Biography: Kazuhiro Ogata


Transcriptional regulationis a fundamental mechanism for cell proliferation and differentiation. A major player in this process is a member of transcription factors (TFs).Activities of TFs are modulated by chemical modifications such as phosphorylation through cell signaling pathways directing cell functions. Molecular mechanisms of regulation for the functional high-order assemblyconsisting of multiple TFs and enhancer DNA (enhanceosome) under cellsignaling are largely unknown. So far, we investigated changes in assembly state of an enhance osome upon a TF’s phosphorylation, using crystallographical, biophysical, and molecular dynamic alanalyses. Here, wewill illustrate the case of Ets1 in non-phosphorylated and phosphorylated forms on its target gene enhancers with or withoutits partner TFs, Runx1/CBF or Pax5, as an example. A structure-function relationship of a TF-DNA assembly and an effect by phosphorylationwill be discussed.