Biography
Biography: Abdisa Tufa
Abstract
Glycomics refers to the broad study of complex carbohydrates, or glycans, in the form of oligosaccharide polymers, N- and O-linked glycoproteins, glycolipids, and proteoglycans. The process of adding these sugars to protein or lipid carriers is termed glycosylation. Normal physiological functions attributed to glycosylation include cellular mechanisms involving cell–cell adhesion, cell motility, inflammation, signal transduction, pathogen–host interactions, and viral entry. However, alterations to any of these processes can easily be linked to various ailments or oncogenesis and cancer progression, and similarly to other fundamental processes like embryogenesis, fertilization and stem cell differentiation. Glycomics composition and concentrations in human varies from individual to individuals since it depends on the food consumption habit, ethnicity, environmental factors and cultural diversity in continents or countries population. The aim of this study to analysis the Ethiopian normal population glycomics profile index which pave the way for new development glycomics-based clinically useful Cancer biomarker for early detection and therapeutic targets by using a variety of approaches and technologies. This research also requires extensive collaborations across institutions with different skills and facilities to accelerate glycan profile in Ethiopia which helps national cancer institute to detect and diagnose cancer at early stages. To complete this, we propose to evaluate the levels of normal glycoproteins in blood samples from healthy voluntary blood donors collected at Tikur Anbessa Specialized Hospital of Addis Ababa University (AAU), Ethiopia. Patients clinically suspected of any chronic diseases will be excluded. Blood drawn from consented normal adult persons (250 physiological persons) will be analyzed by glycobloating technologies both locally at AAU and abroad at Okayama University (Tokyo, Japan).