5th International Conference and Exhibition on Metabolomics
Beijing University of Chinese Medicine, China
Title: Treatment of Natural Plants on Diabetes and Metabolic Syndrome
Biography: Jingxin Zhou
The increasing incidence of diabeties and metabolic syndrome becomes a worldwide threat to global human health. Chinese herbs and natural plants have played an important role in health maintenance for thousand years. Our study have indicated that Chinese medicine including formula, herbal extracts, and compounds mediates the glucose and lipid metabolism. We found Tang-Nai-Kang granules improve the glucose intolerance and insulin resistance by mediating fatty acid oxidation in SHR.Cg-Leprcp/NDmcr rats. Meanwhile, Guava leaf extracts significantly enhanced the insulin-related signaling to activate the insulin signaling and promoting glucose metabolism and fatty acid oxidation, lead to the improvement of insulin sensitivity in the SHRSP/ZF rats. In addition, Isoquercitrin appears to regulate AMPK activation, thereby enhancing AdipoR1 expression, suppressing SREBP-1 and FAS expressions, and resulting in the regulation of lipid accumulation in vivo.