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Takeshi Kimura

Ajinomoto Co., Inc., Japan

Title: LC-MS-based plasma free amino acid profiling for the early detection and risk assessment of cancers and metabolic syndrome

Biography

Biography: Takeshi Kimura

Abstract

Early detection remains the most valuable tool in the fight against chronic diseases. Especially, the need for an early cancer screening method is evident as prognosis depends on how early treatment measures can be taken. Although various analytical platforms exist, currently there are only a few screening tests that have both high sensitivity and the ability for early detection, and also these tests must be taken for each individual cancer. Metabolomics have profound capacity in the search for such candidate markers in that we can obtain comprehensive knowledge and data of metabolisms under specific physiological states. From early observations indicating that amino acids were a convenient subset of the metabolome to investigate changes in metabolism associated with various physiological states, we have developed a technological package (AminoIndex technology) to generate biomarkers for various disease and physiological states using plasma free amino acid concentration data. Risk screening for various cancers with AminoIndex technology have been offered commercially in Japan since 2011. More recently, we have developed novel LC-MS platform that enables high-throughput metabolite profiling including over 40 amino acids, amines and their derivatives. Furthermore, we have constructed a large scale plasma biospecimen bank as well as database containing health and medical information of more than 50,000 Japanese in total concerning multiple diseases (e.g. cancers, metabolic syndrome etc.) and their metabolomic profiles. By variable selection and regression analysis, so far we have developed multivariate indices that enable the early detection of multiple cancers and predictive risk assessment for diabetes and inflammatory bowel disease from a single blood draw. In order to achieve commercialization, various issues ranging from sample handling, throughput to standardization have to be overcome and some of these issues, which may be relevant to other biomarker commercialization, will also be addressed.