Anti-Doping Laboratory Qatar, Qatar
Title: Metabolomics profiling distinguishes elite power and endurance athletes
Biography: Mohamed Elrayess
Background & Aim: The elite performance of professional athletes is associated with alterations in their systemic metabolic profiling. The objectives of this study were to compare the metabolic profiling between low and high power and endurance elite athletes and to highlight the underlying metabolic pathways.
Methods: Sera from one 191 elite athletes who passed anti-doping laboratories’ tests were profiled using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid and gas. Differences in metabolic signatures were compared between low and high power and endurance groups by OPLS-DA and regression models.
Results & Conclusions: Data reveal that high performance athletes show a distinct metabolic profile that reflects steroid biosynthesis, fatty acid metabolism, oxidative stress and energy-related metabolites. Differences in performance-related metabolic profiles could shed light on the biochemical processes associated with their elite performance and potentially be utilized as biomarkers for endurance or power trainability in athletic candidates.