Metabolomics and Enzymology

Metabolomics & Pharmacology

Pharmacogenomics has some impact in clinical practice, through its use to select patient subgroups who will enjoy efficacy without side effects when treated with certain drugs. However, pharmacogenomics, has had less impact than initially predicted. One reason for this is that many diseases, and the way in which the patients respond to drug treatments, have both genetic and environmental elements. Pure genomics is almost blind to the environmental elements. A new methodology has emerged, termed pharmacometabolomics that is concerned with the prediction of drug effects through the analysis of pre-dose, biofluid metabolite profiles, which reflect both genetic and environmental influences on human physiology.