Day 3 :
Associate Professor, University of South Carolina, USA
Time : 09.00-09.50
Mishra received his B. S (Honors) and M.S degrees from Patna University ( then nicknamed as Oxford of the East) in India and Ph. D Degree from McMaster University. He received his post –doctoral training with the late Nobel Laureate Professor E. L. Tatum at the Rockefeller University. He was a Fellow for Medical Research of the Jane Coffin Child Fund of the Yale University at the Rockefeller University for two years and then Research Associate with Professor Tatum where he initiated his work in what is now called as Proteomics and Matabolimics. There he also devised the first gene transfer in a eukaryote, Neurospora crassa.
Later he joined the University of South Carolina Molecular Biology Group and Chairman of the Microbiology dept in the Medical School and remained as Professor of Genetics in the Dept. of Biological Sciences. He was also a Visiting Professor at the Max Planck Institute for Molecular Biology in Heidelberg, Germany and in Genetic Institute of Greenwood, SC.
He has served as a Science advisor to the FAO of the United Nations in India on many occasions and also on the Review Panel of the Human Genome Project of the Dept of Energy, USA. . He is a Fellow for the American Association for the Advancement of Science since 1986 for his contribution to the science of Genetics.
He visited China in May, 2000 supported by the Rockefeller Foundation among the first group of Scientists when China became first open to the West. In addition he has been invited to present his work in Australia, EU, Japan, India and Thailand.
In 1994 Dr. Mishra was one of the invitees to give commencement speech at the Martin Luther University at Halle Wittenberg, Germany organized to celebrate the 300th anniversary of the University : Martin Luther was the one who started Protestantism in Christian religion .
To be updated soon
Departments of Physiology, University of Saskatchewan College of Medicine,Canada
Dr. Joseph Fomusi Ndisang is an Associate Professor in the University of Saskatchewan College of Medicine, Department of Physiology. He received postdoctoral training in Physiology at the University of Saskatchewan College of Medicine from 2000-2005. He obtained a PhD in Pharmacology & Toxicology from the University of Florence, Italy, 2000. He obtained a Doctor of Pharmacy degree from University of Florence, Italy in 1995. He has received several distinguished awards and distinctions including: (i) Fellow of the Canadian Cardiovascular Society (FCCS) in 2016, (ii) Fellow of the American Heart Association (FAHA) in 2011; (iii) Fellow of the International College of Angiology (FICA) in 2007; (iv) Young Investigator Award by International College of Angiology (2007); (v) Young Investigator Award by the American Society of Pharmacology & Experimental Therapeutics-Division for Drug Discovery, Development & Regulatory Affairs (2005); (vi) Young Investigator Award by the Society of Experimental Biology and Medicine (2005); (vii) Caroline tum Suden/Frances A Hellebrandt Professional Opportunity Award for Meritorious Research by the American Physiological Society (2005); and (viii) Recognition Award for Meritorious Research by a Young Investigator by the American Physiological Society (2004).
Top 5% of cited authors in journals of Biology and Biochemistry in 2011, by Thomson-Reuters.
Currently, Dr. Ndisang is an Editor for Frontiers in Bioscience (impact factor 3.8) and Executive Guest Editor for Current Medicinal Chemistry (impact factor 3.7) He has published more than 64-full length manuscripts in peer-reviewed journals and more than 80 abstracts. Dr. Ndisang has served as external PhD examiner for several universities in Canada, has given more than 30-invited talks, and has also served as peer-reviewer for several reputed journals and granting agencies in United States, United Kingdom, Canada, New Zealand and Poland.
Research Interest: His research is mainly focused on investigating the role of the heme oxygenase system in hypertension, diabetes (types-1 and -2), and obesity.
In diabetic subjects, dysfunctional insulin signaling and impaired glucose metabolism are associated with alterations and function of the heart and kidneys. We recently reported that upregulating heme-oxygenase (HO) potentiates insulin signaling and improve glucose metabolism in different animal models of type-1 and type-2 diabetes. Particularly, HO-inducers suppressed inflammatory/oxidative mediators such as cytokines (TNF-α, IL-6, IL-1β), chemokines (MCP-1, MIP-1α), macrophage-M1 infiltration, NF-κB, AP-1, AP-2, cJNk and 8-isoprostane but potentiated insulin-signaling proteins (IRS-1, GLUT4, PI3K, PKB) and reduced insulin/glucose intolerance. These were associated with reduced cardiac lesions (hypertrophy, collagen deposition in cardiomyocytes and left ventricular longitudinal muscle-fiber thickness) and renal lesions (glomerulosclerosis, tubular necrosis, tubular vacuolization, interstitial macrophage infiltration and pro-fibrotic/extracellular-matrix proteins like collagen and fibronectin that deplete nephrin, a protein which forms the scaffolding of the podocyte slit-diaphragm for filtration). Correspondingly, improved cardiac hemodynamics and reduced proteinuria was observed suggesting improved cardiac and renal functions.
These data suggest that HO may be explored in the search for novel and effective remedies against cardio-renal complications
Assistant Professor,King Saud University
Dr. Ali Alanazi has an extensive background in Biomedical engineering in Saudi Arabia and Japan, as a researcher, trainer, and organizer of biomedical engineering programs implementation.
In addition, skilled in management, development, implementation of new programs; train and supervise biomedical engineers in planning, maintenance, and inventory systems for newly installed equipment and instrumentation
Medical Application of Diamond like Carbon (DLC) Coating
Artificial heart forms a specific intervention that can be used for treating various heart diseases. Silicon oil is used as a pillar for the artificial heart. However, certain problems may arise with the silicon oil ions as they diffuse with the blood through ion penetration. There are seven various forms of Diamond like Carbon (DLC). All forms have a high value of sp3 hybridized carbon atoms. DLC can be found in more than one types primarily because the diamond is produced in two different crystalline poly-types. DLC coatings exhibit great combination chemical, mechanical, and electrical properties. As compared to the conventional hard coatings, they can be produced at very low temperatures without compromising its hardness. The study examined use of micro-hardness tester, the AFM, and the DLC films deposited because of R.F. plasma discharge. It is apparent that the roughness and hardness of films depend upon the bias voltage provided to the substrates and upon the pressure exerted on the deposition chamber. Artificial hearts contain power adapter, blood type diaphragm, two oval pumps, and multiple electronic modules. The power adapter plays an important role in delivering hydraulic silicone oil into the blood as it is pumped through a pair of oil channels. The rotating pulse of silicone oil makes circulation more flexible. Use of planar electrodes form the most popular method of operation while the RF plasma are used. It, therefore, is not easy to uniformly deposit the DLC film upon the surfaces of insulator material especially when a three-dimensional shape is used. DLC films are used for coating ellipsoidal diaphragm (polyurethane elastomer) and yet forms an influential biomaterial for functioning of the artificial hearts. Such coatings are done to prevent penetration of the hydraulic silicone oil to blood through the diaphragm.
Prof. Hari Misra is currently Head, Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, India. For last 27 years, Dr Misra has been working on molecular and cellular responses of bacteria to both oxidative stress and DNA damage effects of gamma radiation. He has identified a novel antioxidant / radioprotector, which is found to be a ubiquitous response regulator from one of the most radioresistant bacterium, Deinococcus radiodurans. Catching tail of this molecule, his group discovered a new type of DNA damage response mechanism that seems to be an alternative to the missing classical LexA/RecA type SOS response in this bacterium. Dr. Misra’s current research interests are “Bacterial Genome Biology, Molecular and Cellular responses to oxidative stress and DNA damage, Molecular Genetics and structure-function of proteins, Metabolic engineering and antioxidant / radioprotector / redox biology. Dr Misra has published ~70 research papers in national and international journals of very high repute, with an aggregate IF ~198 and SCI >1000 (Scopus) and >1400 (Goggle scholar). For these contributions, Dr Misra is bestowed with a number of national /international recognitions / awards like “Indian Science Congress- Platinum Jubilee Lecture Award, Homi Bhabha Science and Technology Award, Sarma Memorial Award, DAE Science and Technology Excellence Award, INS Young Scientist Award”. He is elected member of “Guha Research Conference”. Dr Misra is a fellow of National Academy of Sciences, India (FNASc) and Maharashtra Academy of Sciences (FMASc) and Fulbright-Nehru Senior Fellow. Dr Misra has been visiting Scientist/Professor to Harvard Medical School Boston, UTSW-MC Dallas, LSU, Baton Rogue, Zhijiang University China and Korean Atomic Energy Research Institute, Republic of South Korea. He is a Member of BoS and Ph.D. thesis examiner to a number of highly reputed institutions in India. Dr Misra is a member of the American Society of Biochemistry and Molecular Biology (ASBMB), American Society of Microbiologists (ASM), Society of Biological Chemists of India, Association of Microbiologists of India, Environmental Mutagenic Society of India., Indian Society of Cell Biology and Indian Nuclear Society, and has been office bearers of academic societies in India.
To be updated soon