Muhammed Alzweiri
The University of Jordan, Jordan
Title: Acetylated ferulenol-oxy-ferulenol as a proposed marker for fresh ferula toxicity: A metabolomic approach
Biography
Biography: Muhammed Alzweiri
Abstract
Toxicity of fresh Ferula communis (Apiaceae) among cattle in North Jordan is a recently reported problem. Ferula toxicity "Ferulosis" is still ambiguous and not fully understood. Metabolomic approach was applied in the present study to address this problem. Metabonomics based on Attenuated Total Reflectance/Fourier Transformed-Infrared (ATR/FT-IR) results showed that chloroform extract of fresh F. communis has constituents significantly different than those detected in dried plants. Additionally, metabolomics based on HPLC analysis revealed a chromatographic peak with higher concentration in fresh samples. Based on the mass fragments (620, 549, 371 and 274) m/z and neutral losses of acetyl groups (549-505) m/z and (505-461) m/z this compound was identified as acetylated ferulenol-oxy-ferulenol (AFOF).