Metabolomic profiling

Metabolic profiling is the measurement of genetic modification and physiological, pathophysiological, and/or developmental stimuli in biological systems of the complement of low-molecular-weight metabolites and their intermediates that reflects the dynamic response. From a biological sample (typically urine, serum, or biological tissue extract)  The measurement and interpretation of the endogenous metabolite profile have provided many opportunities to investigate the changes induced by external stimuli (e.g., drug treatment) or enhance our knowledge of inherent biological variation within subpopulations.
"investigating preclinical drug development issues Metabolic profiling can complement conventional methodologies and other “omics” technologies." " in improving our understanding of phospholipidosis and peroxisome proliferation Case studies will illustrate the value of metabolic profiling.". " in support of toxicology and pathology investigations in preclinical drug development A key message will be that metabolic profiling offers huge potential to highlight biomarkers and mechanisms ."

 

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