Pharmacogenomics

Pharmacogenomics

The study of the role of the genome in medication response is known as pharmacogenomics. The combination of pharmacology and genetics is reflected in the term (pharmaco- + genomics). Pharmacogenomics studies how a person's genetic composition influences their pharmacological reaction. It examines the impact of acquired and inherited genetic variation on drug response in patients by linking gene expression or single-nucleotide polymorphisms to pharmacokinetics (drug absorption, distribution, metabolism, and elimination) and pharmacodynamics (effects mediated by a drug's biological targets). The terms pharmacogenomics and pharmacogenetics are frequently used interchangeably. Although both names refer to medication response influenced by genetic factors, pharmacogenetics focuses on single drug-gene interactions, whereas pharmacogenomics takes a more genome-wide approach, including genomics and epigenetics while addressing the impact of numerous genes on drug response.

 

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